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   THYROID HORMONES
 

Thyroid hormone transport proteins
Vivian Cody, Ph.D.

vivianDr. Vivian Cody is working with scientists in Melbourne, Australia to understand the role of evolution on the function of thyroid hormone transport proteins. Currently studies are underway to determine the three dimensional structure of lamprey transthyretin (TTR), a thyroidthyroid hormone transport protein, to compare its hormone binding site with that of the newly discovered homolog, transthyretin-like protein (TLP) that shares 60% sequence homology with human transthyretin, but does not bind thyroid hormone. TLP genes have been observed in all kingdoms whereas TTR genes are only found in vertebrate genomes.  These data suggest that TTR genes may have evolved from the duplication of the TLP gene in early vertebrate evolution.

 
 
     
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